Andarine S4: Uses, Side-Effects, Safety & Research

Andarine is a selective androgen receptor modulator or, in short, SARM. A pharmaceutical company designed it for the treatment of muscle-wasting conditions.

Researchers quickly noticed that this product has some serious effects like muscle building, recovery, and even performance while having minimal side effects.

Andarine S4 is still an investigational drug and is not approved by the FDA, in fact, Andarine is currently on the dietary supplement advisory list of the FDA.

Despite it being on this list, people still bought and used it for these muscle-building effects. But how does it actually work, and is it safe to use? Let’s find out in this article. We will tell you everything you need to know about this compound.

You can find the latest research on Andarine S4 over here. If you’re just here to find out what the best source is for Andarine S4, we would recommend Chemyo, click here to go to their website.

What is Andarine?


Andarine, also known as GTx-007 and S-4, is an investigational drug designed to help treat various muscle-wasting diseases. Researchers wanted to create a drug with the benefits of anabolic androgen steroids but without the side effects.

They found a way to do that and called it a selective androgen receptor modulator because it selectively binds to the androgen receptor, which increases lean muscle mass and strength. 

The company behind Andarine is GTX Inc., and they are also the developers of Ostarine MK-2866. They started research with Andarine and later discovered Ostarine to be more potent and with more minor complications.

Andarine is currently not being developed anymore, but research chemical vendors like Chemyo and Sports Technology Labs are still selling it.

Effects & Benefits

Let’s take a closer look at the possible effects of Andarine S4. Since it’s still an investigational drug, the short and long-term impacts of this SARM are not all discovered. The effects and benefits you find below are gathered from the latest research and anecdotal experiences.

Accelerates muscle growth

It has been shown that Andarine has the ability to stimulate the androgen receptor(AR) in rats. A study showed that S4 had a high binding affinity to the AR without causing much suppression.

It also showed to have a higher anabolic ratio than regular testosterone in rats. 

Increased Muscle Strength

Because of the increased AR stimulation and muscle mass, there have been rumors of reports of people that improved muscle strength and overall performance.

There have been cases of people that gained 20 lbs on their bench press after a cycle of Andarine. Of course, these increases are dose-dependent but can also depend on how you react to the compound.

Fat Burning Properties

A study showed that S4 could potentially have fat-burning properties. While there isn’t much data available, it showed some interesting things. The rats in this study who took S4 gained muscle mass and bone density while losing body fat.

Some people speculate that it could be because of the increased muscle mass and, therefore, the increased metabolic rate. 

Andarine S4 anabolic activity

Does Andarine Have Side Effects?

There has been lots of debate on the effects of Andarine and if the adverse effects shown in the studies are worth the risk.

Some severe side effects were noticed in the latest studies, which made GTX Inc. question the effectiveness of this SARM. 

The following side effects were noticed in studies but also in anecdotal experience:

  • Yellow vision tint in the eyes
  • Testosterone suppressive

The yellow vision has been noticed with almost any dosages. However, the higher the dosage, the more it will pronounce. The vision side effect hasn’t been detected with any other SARM. The raw ingredient Andarine also has a yellow color, which is probably the reason for the yellow tint.

However, it’s a profound side effect and shouldn’t be taken lightly at all. While most users comment that vision loss restores back to normal after usages, it’s definitely something to consider if you would like to use it.

Another side effect of Andarine is that it suppresses your natural testosterone. This is very common with compounds that are known to bind with the androgen receptor and your natural test production. 

You can easily combat this with a SARMs PCT product like Rebirth PCT.

There have been multiple reports of people claiming SARMs to be liver toxic, and a study done on this showed that this could potentially be true; however, more data is needed. Andarine doesn’t seem to be very liver-toxic, but more research needs to be done.

Dosage & Cycle

Let’s talk about Andarine dosage and cycles. First of all, we wouldn’t recommend using this SARM since it’s still in the research stage, and some severe side effects are associated with Andarine, such as the loss of vision.

There are also no human studies available only in rats. While this can give you a good idea of what it could do in humans, it’s not 100% accurate.

The latest studies used dosages ranging from 3 to 10mg per kg body weight. If we look at the anecdotal experience, we will see that most users take a dosage between 25mg to 100mg per day. 

There is no optimal dosage established. However, most users would say an Andarine dosage of 50mg is optimal. Most users also experience vision side effects at this dosage. 

A general cycle of Andarine would be 50mg split into 2 dosages for 8 weeks. A PCT product like Rebirth PCT would be highly advised because S4 has been shown to be suppressive.

We wouldn’t recommend going any higher than 100mg a day because of the vision side effects occurring rapidly at a higher dose.

Half Life Of Andarine S4

There is not much data available on the half-life. However, multiple studies have referenced that Andarine should have a half-life of 4 hours.

Many people suggested that 4 hours is not valid as the side effects of this compound stayed in their system for a couple of days. Some indicated that Andarine could have a half-life of 24-48 hours.

Results: What can you expect?

Andarine is known as a muscle hardener and could give you that dry muscle look. It’s one of the best SARMs for cutting because of the look it can give you on lower body fat.

It’s not as good as a muscle builder as LGD-4033 or RAD-140, but it’s still very potent and works very efficiently. 

Many users use it in a SARMs stack with Ostarine because of the synergetic effects. 

With Andarine, you can expect dry and lean muscle gains, similar to Ecdysterone. There have been reports of people gaining up to 20 lbs of lean muscle mass after a cycle of Andarine.

Andarine vs. Ostarine

Ostarine is often compared to Andarine because of its similar dry and lean muscle gains. However, there is a big difference between the 2. The most significant difference is that Ostarine, also called MK-2866, has way more studies and human studies done.

Another difference is that Ostarine has been shown to be safer and generally well tolerated when using it. People see MK-2866 as a mild and beginner compound, but it’s very efficient and highly anabolic. 

They both seem to give a decent amount of lean muscle mass, but Andarine is preferred as a cutting drug because of its dry look. Most users like to stack these together to get the best of both of them.

Andarine For Sale

There are a couple of places that sell Andarine S4. However, not all of them are of the same quality. When you want to buy products like SARMs, we would highly advise buying only from a trusted source.

Luckily for you, we have already tested out multiple SARM vendors and concluded that Chemyo is the best one. They provide third-party lab testing with every product and batch, which is very important, and not all vendors do this.

If you buy from this source, you know that you are getting quality products. You definitely don’t wanna buy something from a sketchy website. Other sources we would recommend are Sports Technology Labs or Swiss Chems.

Andarine for sale

Conclusion: Would we Recommend?

Andarine is a selective androgen receptor modulator and was one of the first SARMs to be discovered. It has been discontinued research, so no new clinical data will be available.

In studies, it has been shown to increase performance, overall muscle mass, and fat-burning properties

There are some serious adverse effects noted with this SARM, which you shouldn’t take lightly. It’s highly advised to make use of post-cycle therapy because of its suppressive effects.

We’ve seen many users combine it with Ostarine as a fat-burning and muscle-building protocol. It’s up to you to decide if you would like to take it and if it’s worth the risk. However, if you’re keen on using it, make sure to use our trusted source.

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