Cardarine: Examination Of GW501516 – Is It Safe & Effective?

Before introducing you to Cardarine, it’s essential to know that it is not a selective androgen receptor modulator. 

Many of the popular SARMs vendors market and distribute it as one, but it’s actually a PPAR Agonist.

If you aren’t familiar with PPAR agonists, you can read more about these compounds and their benefits by clicking here.

With that said, we can move on and walk you through the compound that goes by the name of Cardarine. 

Cardarine (GW501516) Introduction


GW501516, most commonly known as Cardarine or Endurobol, is a peroxisome proliferator-activated receptor (PPAR Agonist).

A collaboration of two pharmaceutical companies developed it. One of them is Ligand Pharmaceuticals, known for developing LGD4033 (Ligandrol).

Animal testing had shown Cardarine to be a potentially effective treatment for metabolic-related diseases (1). It has proved to increase exercise capacity significantly. 

Unfortunately, it ended up causing complications in the animals’ health during clinical trials. All research came to an end back in 2007 because it was not deemed safe.

Due to GW501516’s effectiveness in boosting stamina and performance, WADA has added it to the prohibited compound list.

What Is Cardarine Used For?

Cardarine used to be researched for the possibility of helping treat metabolic and cardiovascular diseases (2).

Nowadays, athletes use Cardarine to enhance physical and exercise performance.

Because of the compound’s ability to rapidly increase performance, it’s gotten extremely popular amongst bodybuilders.

When we look at anecdotal user reports, you will find that it boosts stamina, endurance, workout capacity, and fat loss after just days of usage.

What is cardarine used for

Athletes also use Cardarine to stack with SARMs. Selective Androgen Receptor Modulators focus on building muscle tissue, whereas they use GW501516 to focus on stamina and weight loss.

We’ve put together a write-up of the Best SARMs on the market; make sure to give it a read.


Many of you want to know what type of results you can expect from using GW501516.

The main things you can expect will be accelerated fat loss, improved stamina, and more endurance.

For this reason, many athletes use it for cutting and not for bulking. During a cut, a compound like this will help speed up stubborn fat loss and make cardio easier.

In several user reports, we’ve seen that the results can be significant when used correctly.

It’s not unheard of to lose 10 lbs in 6 weeks while using it. Of course, caloric intake and exercise will also play a part in the results.

When using it during a cut, many users will throw in another product to help them build and preserve muscle mass.

A popular combination would be Endurobol and Ostarine.

Cardarine Dosage Information

To fully experience the exercise boosting capabilities, you need to know what the most effective dose is.

When we look at the many users’ reports found online, we can conclude that the most effective Cardarine dosage is between 10 to 20mg per day.

At this dosage, one could fully experience the many benefits it has to offer.

The full dose is usually taken one to two hours before exercising. Generally speaking, a cycle will last anywhere from 4 to 8 weeks.

Cardarine dosage information

After you have completed a cycle, you do not require a post cycle therapy because it does not conflict with hormones.

Many bodybuilders and athletes stack Endurobol with Ostarine or Andarine to create the Triple Stack.

You can buy cardarine from Chemyo since they have the highest quality available.


The half-life of Cardarine (GW501516) is between 12 to 24 hours. It is advised to dose it just once per day.

Are There Any Side Effects?

Unfortunately, we can’t conclude whether this product doesn’t cause any side effects. 

During human trials, participants were given various dosages of Cardarine for two weeks and reported no significant side effects (3).

When we look at users that have researched this compound, they also claim to have experienced little to no side effects.

It’s important to know that the research on GW501516 was suspended because animal testing was shown to cause tumor formation. 

It is worth mentioning that these animals received a large dosage for more extended periods. For comparison, it was 43.2mg per day for a 200-pound (90kg) male for 104 weeks.

Nobody knows what the long-term use of this product can have on humans.

If you plan to research this compound, make sure to read all available information on dosages, side effects, and all other relevant topics.

Where To Buy Cardarine?

We’ve shown you all there is to this compound, and now you want to know where you can buy Cardarine.

Perhaps you’ve already done a few web searches and found a few places that have it in stock.

We at Nectac highly recommend checking out Chemyo as they have high-quality Cardarine for sale.

They also have SR9009 (Stenabolic) and YK-11.

You’ll also find that they have hundreds of positive user experiences online.

We have tested the GW501516 they carry, and it worked. They prove that they sell an authentic product by conducting third-party tests on the website.

Do not take the risk by buying from a cheap or unreliable vendor. At the end of the day, it’s a research chemical, and you want to make sure you’re getting a high-quality product. Are you looking for a trusted source of SARMs? Make sure to check out our SARMs buying guide.

Cardarine Frequently Asked Questions

When Do I Take Cardarine?

It’s advised to take Cardarine roughly one to two hours before starting a workout.

How long does it take for cardarine to work?

It only takes a few days for Cardarine to start working. With that said, it is essential to have made sure that you have bought it from a reliable vendor like Chemyo.

Is GW501516 Safe?

Unfortunately, because the research on GW501516 is limited, we can’t tell you it 100% safe to use.

It’s still an investigational product that has not been approved.

Can I Stack It?

It’s possible to stack it with other compounds. Most athletes prefer to combine it with SARMs.

We’ve done several writeups on popular SARMs such as RAD140 and even MK677. Check them out to see if they suit your goals.


Cardarine might have the ability to boost endurance and stamina uniquely.

The best dosage is said to be between 10-20mg per day for 4-8 weeks.

Unfortunately, no new research will become available because it has been discontinued.

We can’t conclude that it’s safe. Make sure to read through the studies to understand the product thoroughly.

If you plan to research GW501516, get it from our recommended vendor, Chemyo.

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